Accession: ENSP00000428714 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000428714 (Len=1278)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000428714, Len=1278):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTR 80  
WD40-rpts                                                                                      

Query       81 MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVA 160 
WD40-rpts                                                                                      

Query      161 QYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPP 240 
WD40-rpts                                                                                      

Query      241 GPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPL 320 
WD40-rpts                                                                                      

Query      321 QWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRV 400 
WD40-rpts                                                                                      

Query      401 QSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQF 480 
WD40-rpts                                                                                      

Query      481 YKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIA 560 
WD40-rpts                                                                                      

Query      561 MPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYL 640 
WD40-rpts                                                                                      

Query      641 YLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKK 720 
WD40-rpts                                                                                      

Query      721 FKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNE 800 
WD40-rpts                                                                                      

Query      801 CVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTE 880 
WD40-rpts                                  (_______________________________________________WD 1

Query      881 CDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKH 960 
WD40-rpts      _______________________________________________)                                

Query      961 KINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVW 1040
WD40-rpts      (_________________WD 2________________)           (__________________WD 3_______

Query     1041 VGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLH 1120
WD40-rpts      ___________)   (__________________WD 4__________________)   (_________________WD

Query     1121 GGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDC 1200
WD40-rpts       5________________)     (_________________WD 6_________________)    (___________

Query     1201 SEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE 1278
WD40-rpts      _________WD 7___________________)   (_________________WD 8_________________)

8 WD40-repeats found in QUERY=ENSP00000428714 (Len=1278):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 12   829-928      3.33  252.15  0.02462       27.5%      1.88
  WD 2:  Seg 13   961-999      7.12  408.73  0.00019       15.0%     31.79
  WD 3:  Seg 17  1011-1052     6.11  367.09  0.00070       22.5%     40.98
  WD 4:  Seg 20  1056-1097     7.97  443.84  6.5e-05       30.0%     48.64
  WD 5:  Seg 24  1101-1139     6.62  388.10  0.00037       12.5%     43.08
  WD 6:  Seg 28  1145-1184     5.82  355.04  0.00102        7.5%     43.72
  WD 7:  Seg 32  1189-1233     3.99  279.35  0.01066       15.0%     35.81
  WD 8:  Seg 36  1237-1276     5.92  359.33  0.00089       25.0%     49.23

Multiple sequence alignment of 8 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1  829-928    TEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIR----VASKKEVFEANLKTEC------DLWHLMVKEMWAGK---KLADDH--KDPHYVQQALTNVLLMDAVVGT-LQSPG
   WD 2  961-999    -KINPSAGEAFPQ-------AVD-----------VLL----YT-------------P------G-----------HL---DPAEKV--ED------------------AH-PKLWC
   WD 3 1011-1052   --ASSWTIHQHSF-------KVG-----------TAKVNCMVM-------------A------D-----------QN---QVWVGS--ED------------------SV-IYIIN
   WD 4 1056-1097   -MSCNKQLTAHCS-------SVT-----------DLI----VQ-------------D------G-----------QEAPSNVYSCS--MD------------------GM-VLVWN
   WD 5 1101-1139   -LQVTSRFQLPRG-------GLT-----------SIR----LH-------------G------G-----------RL---WCCTGN--SI------------------MV-MKMNG
   WD 6 1145-1184   -LKIEENFKDTST-------SFL-----------AFQ----LL-------------P------E-----------EE---QLWAAC--AG------------------RSEVYIWS
   WD 7 1189-1233   -AQPPQRVPLEDC-------SEI-----------NCM----IR-------------VKKQVWVG-----------SR---GLGQGT--PK------------------GK-IYVID
   WD 8 1237-1276   -KTVEKELVAHMD-------TVR-----------TL-----CS-------------A------E-----------DR---YVLSGSGREE------------------GK-VAIWK

   WD40 Template    TGECLRTLSGHTS-------GVT-----------SVS----FS-------------P------D-----------GK---RLVSGS--ED------------------GT-IKVWD