Accession: ENSP00000428276 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000428276 (Len=1203)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000428276, Len=1203):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 XPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPP 80  
WD40-rpts                                                                                      

Query       81 RAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPG 160 
WD40-rpts                                                                                      

Query      161 CFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPE 240 
WD40-rpts                                                                                      

Query      241 SPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTS 320 
WD40-rpts                                                                                      

Query      321 FLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRDVKNHLNYEHRVFNSEEFLKTRAP 400 
WD40-rpts                                                                                      

Query      401 GDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPN 480 
WD40-rpts                                                                                      

Query      481 LQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLL 560 
WD40-rpts                                                                                      

Query      561 LARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLD 640 
WD40-rpts                                                                                      

Query      641 DHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEH 720 
WD40-rpts                                                                                      

Query      721 LDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEA 800 
WD40-rpts                                       (______________________________________________

Query      801 NLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTL 880 
WD40-rpts      _WD 1_______________________________________________)                           

Query      881 ETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMAD 960 
WD40-rpts           (_________________WD 2________________)           (__________________WD 3__

Query      961 QNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLT 1040
WD40-rpts      ________________)   (__________________WD 4__________________)   (______________

Query     1041 SIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRV 1120
WD40-rpts      ___WD 5________________)     (_________________WD 6_________________)    (______

Query     1121 PLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIW 1200
WD40-rpts      ______________WD 7___________________)   (_________________WD 8_________________

Query     1201 KGE 1203
WD40-rpts      )

8 WD40-repeats found in QUERY=ENSP00000428276 (Len=1203):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 15   754-853      2.82  231.19  0.04667       20.0%      0.18
  WD 2:  Seg 16   886-924      6.69  390.91  0.00034       15.0%     32.50
  WD 3:  Seg 20   936-977      5.88  357.36  0.00095       22.5%     40.56
  WD 4:  Seg 23   981-1022     7.89  440.59  7.2e-05       30.0%     49.21
  WD 5:  Seg 27  1026-1064     6.26  373.43  0.00058       12.5%     42.95
  WD 6:  Seg 31  1070-1109     5.53  343.12  0.00148        7.5%     43.63
  WD 7:  Seg 35  1114-1158     3.70  267.60  0.01531       15.0%     36.84
  WD 8:  Seg 39  1162-1201     5.90  358.50  0.00092       25.0%     50.05

Multiple sequence alignment of 8 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1  754-853    TEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLK----IRV------ASKKEVFEANLKTECDLWHLMVKEMWAGK---KLADDH--KDPHYVQQALTNVLLMDAVVGT-LQSPG
   WD 2  886-924    -KINPSAGEAFPQ----------------AVDVLL----YTP------G--------------------------HL---DPAEKV--EDA------------------H-PKLWC
   WD 3  936-977    --ASSWTIHQHSF----------------KVGTAKVNCMVMA------D--------------------------QN---QVWVGS--EDS------------------V-IYIIN
   WD 4  981-1022   -MSCNKQLTAHCS----------------SVTDLI----VQD------G--------------------------QEAPSNVYSCS--MDG------------------M-VLVWN
   WD 5 1026-1064   -LQVTSRFQLPRG----------------GLTSIR----LHG------G--------------------------RL---WCCTGN--SIM------------------V-MKMNG
   WD 6 1070-1109   -LKIEENFKDTST----------------SFLAFQ----LLP------E--------------------------EE---QLWAAC--AGR------------------SEVYIWS
   WD 7 1114-1158   -AQPPQRVPLEDC----------------SEINCM----IRVKKQVWVG--------------------------SR---GLGQGT--PKG------------------K-IYVID
   WD 8 1162-1201   -KTVEKELVAHMD----------------TVRTL-----CSA------E--------------------------DR---YVLSGSGREEG------------------K-VAIWK

   WD40 Template    TGECLRTLSGHTS----------------GVTSVS----FSP------D--------------------------GK---RLVSGS--EDG------------------T-IKVWD