Accession: ENSP00000426669 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000426669 (Len=1505)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000426669, Len=1505):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 XDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTE 80  
WD40-rpts                                                                                      

Query       81 IEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLL 160 
WD40-rpts                                                                                      

Query      161 QDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLT 240 
WD40-rpts                                                                                      

Query      241 TASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKAT 320 
WD40-rpts                                                                                      

Query      321 PSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTN 400 
WD40-rpts                                                                                      

Query      401 AVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLL 480 
WD40-rpts                                                                                      

Query      481 GSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQR 560 
WD40-rpts                                                                                      

Query      561 AEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWED 640 
WD40-rpts                                                                                      

Query      641 DLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPV 720 
WD40-rpts                                                                                      

Query      721 SLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMA 800 
WD40-rpts                                                                                      

Query      801 NRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYN 880 
WD40-rpts                                                                                      

Query      881 DLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRI 960 
WD40-rpts                                                                                      

Query      961 EPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAK 1040
WD40-rpts                                                                                      

Query     1041 TSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTP 1120
WD40-rpts                                                                                      

Query     1121 SQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQG 1200
WD40-rpts                                                                                      

Query     1201 AVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHW 1280
WD40-rpts                                                                           (__________

Query     1281 DVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQE 1360
WD40-rpts      _________WD 1__________________)                (_________________WD 2__________

Query     1361 GPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGG 1440
WD40-rpts      ______)                                           (_________________WD 3________

Query     1441 DRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY 1505
WD40-rpts      ________)(__________________WD 4__________________)

4 WD40-repeats found in QUERY=ENSP00000426669 (Len=1505):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 18  1270-1312     5.25  331.57  0.00212       30.0%     53.23
  WD 2:  Seg 22  1329-1367     3.41  255.71  0.02207       22.5%     54.00
  WD 3:  Seg 30  1411-1449     4.58  303.92  0.00498       22.5%     56.34
  WD 4:  Seg 34  1450-1491     4.30  292.42  0.00712       22.5%     52.27

Multiple sequence alignment of 4 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1 1270-1312   -GRL--IQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWY
   WD 2 1329-1367   -AAP--RAILTGHDYEVTCAAVCAE----LGLVLSGSQEGPCLIHS
   WD 3 1411-1449   NGKL--QATME-TDDNIRAIQLSRD----GQYLLTGGDRGVVVVRQ
   WD 4 1450-1491   VSDLKQLFAYPGCDAGIRAMALSYD----QRCIISGMASGSIVLFY

   WD40 Template    TGEC--LRTLSGHTSGVTSVSFSPD----GKRLVSGSEDGTIKVWD