Accession: ENSP00000415639 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000415639 (Len=475)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000415639, Len=475):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKENQPENS 80  
WD40-rpts                                                                                      

Query       81 QTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRND 160 
WD40-rpts                                    (_______________WD 1______________)   (___________

Query      161 YYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM 240 
WD40-rpts      _____WD 2________________)(___________________WD 3___________________)   (______

Query      241 TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGG 320 
WD40-rpts      __________WD 4_______________)    (_________________WD 5________________)       

Query      321 WVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 400 
WD40-rpts      (__________________WD 6__________________)   (_________________WD 7_____________

Query      401 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR 475 
WD40-rpts      ____)   (_________________WD 8________________)

8 WD40-repeats found in QUERY=ENSP00000415639 (Len=475):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  2   111-145      2.99  238.15  0.03777       12.5%     12.18
  WD 2:  Seg  4   149-186      4.95  319.04  0.00312       12.5%     46.38
  WD 3:  Seg  8   187-230      7.74  434.49  8.7e-05       20.0%     58.21
  WD 4:  Seg 12   234-270      6.89  399.34  0.00026       32.5%     52.53
  WD 5:  Seg 16   275-313      9.62  511.97  7.8e-06       37.5%     49.29
  WD 6:  Seg 20   321-362      6.21  371.37  0.00062       25.0%     43.41
  WD 7:  Seg 24   366-405      6.31  375.33  0.00054       35.0%     52.35
  WD 8:  Seg 28   409-447      9.74  517.10  6.7e-06       37.5%     54.97

Multiple sequence alignment of 8 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1  111-145    -GK----PQNAPEGYQNRLKVLY----SQKATP---GSS--RKTCRYIP
   WD 2  149-186    -DR----ILDAPEIRNDYYLNLVDWSSGNVLAV---AL---DNSVYLWS
   WD 3  187-230    ASSGDILQLLQMEQPGEYISSVAWIKEGNYLAV---GTS--SAEVQLWD
   WD 4  234-270    -QK----RLRNMTSHSARVGSLSW--NSYILSS---GSR--SGHIHHHD
   WD 5  275-313    -EH----HVATLSGHSQEVCGLRWAPDGRHLAS---GGN--DNLVNVWP
   WD 6  321-362    -WV----PLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS--DRHIRIWN
   WD 7  366-405    -GA----CLSAVDAH-SQVCSILWSPHYKELIS---GHGFAQNQLVIWK
   WD 8  409-447    -MA----KVAELKGHTSRVLSLTMSPDGATVAS---AAA--DETLRLWR

   WD40 Template    TGE----CLRTLSGHTSGVTSVSFSPDGKRLVS---GSE--DGTIKVWD