Accession: ENSP00000380135 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000380135 (Len=698)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000380135, Len=698):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 TPAGPQAPHSAPVPASISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNI 80  
WD40-rpts                                                                                      

Query       81 VRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQT 160 
WD40-rpts                                                                                      

Query      161 DVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQ 240 
WD40-rpts                                                                                      

Query      241 EKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYRDQVGTLLP 320 
WD40-rpts                                                                                      

Query      321 LWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAV 400 
WD40-rpts                                                      (___________________WD 1________

Query      401 GHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVE 480 
WD40-rpts      __________)         (___________________WD 2__________________)                 

Query      481 GSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSS 560 
WD40-rpts                                                      (_________________WD 3__________

Query      561 DWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIH 640 
WD40-rpts      _______)(__________________WD 4__________________)(____________________WD 5_____

Query      641 PIIIVGDDRGHIISLKLSPNLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT 698 
WD40-rpts      _______________)

5 WD40-repeats found in QUERY=ENSP00000380135 (Len=698):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  8   369-411      3.08  241.88  0.03372       17.5%     46.64
  WD 2:  Seg 12   421-463      3.96  278.31  0.01100       25.0%     37.31
  WD 3:  Seg 19   529-568      5.78  353.22  0.00108       37.5%     44.01
  WD 4:  Seg 22   569-610      3.05  240.44  0.03522       17.5%     45.69
  WD 5:  Seg 26   611-656      3.52  260.01  0.01935       17.5%     56.52

Multiple sequence alignment of 5 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1  369-411    LKN------PSFPEYMF-SSNSGVMCLDIHV-D---HPYLV-AVGHYDGNVAIYN
   WD 2  421-463    FCS------SA--KS-G-KHSDPVWQVKWQK-DDMDQNLNF-FSVSSDGRIVSWT
   WD 3  529-568    -SQ------FL--DTYD-AHNMSVDTVSWNPYH----TKVF-MSCSSDWTVKIWD
   WD 4  569-610    HTI------KT--PMFIYDLNSAVGDVAWAP-Y----SSTVFAAVTTDGKAHIFD
   WD 5  611-656    LAINKYEAICN--QPVA-AKKNRLTHVQFNL-I----HPII-IVGDDRGHIISLK

   WD40 Template    TGE------CL--RTLS-GHTSGVTSVSFSP-D----GKRL-VSGSEDGTIKVWD