Accession: ENSP00000379029 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000379029 (Len=1675)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000379029, Len=1675):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGY 80  
WD40-rpts                                                                                      

Query       81 NATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLF 160 
WD40-rpts                                                                                      

Query      161 DTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVC 240 
WD40-rpts                                                                                      

Query      241 PQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATH 320 
WD40-rpts                                                                                      

Query      321 VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMEL 400 
WD40-rpts                                                                                      

Query      401 MEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIH 480 
WD40-rpts                                                                                      

Query      481 SYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQ 560 
WD40-rpts                                                                                      

Query      561 KLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEK 640 
WD40-rpts                                                                                      

Query      641 ANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSE 720 
WD40-rpts                                                                                      

Query      721 YEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKK 800 
WD40-rpts                                                                                      

Query      801 DQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQ 880 
WD40-rpts                                                                                      

Query      881 KMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKR 960 
WD40-rpts                                                                                      

Query      961 REKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYL 1040
WD40-rpts                                                                                      

Query     1041 LDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDST 1120
WD40-rpts                                                                                      

Query     1121 DEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTE 1200
WD40-rpts                                                                                      

Query     1201 TSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSDSGTSEASLSPPSSPPSRP 1280
WD40-rpts                                                                                      

Query     1281 RNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHSRSSRRGIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDL 1360
WD40-rpts                                                                     (_____________WD 

Query     1361 LFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDACSA 1440
WD40-rpts      1____________)         (_____________WD 2_____________)                         

Query     1441 STSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQISSGQDLIITGSKDHYI 1520
WD40-rpts                                    (________________________WD 3_____________________

Query     1521 KMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVL 1600
WD40-rpts      ___)(____________________WD 4____________________)       (_______________WD 5___

Query     1601 LSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLGEDIASN 1675
WD40-rpts      ____________)   (________________WD 6_______________)

6 WD40-repeats found in QUERY=ENSP00000379029 (Len=1675):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 14  1344-1374     4.55  302.77  0.00516       35.0%     27.96
  WD 2:  Seg 17  1384-1415     3.35  252.90  0.02406       30.0%     39.64
  WD 3:  Seg 23  1471-1524     3.46  257.45  0.02093       32.5%     44.29
  WD 4:  Seg 27  1525-1570     3.89  275.22  0.01211       32.5%     24.49
  WD 5:  Seg 29  1578-1613     2.98  237.83  0.03814       22.5%     34.29
  WD 6:  Seg 31  1617-1653     3.11  243.24  0.03235       15.0%     31.26

Multiple sequence alignment of 6 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1 1344-1374   ------------------AEG--------HTKAV--LCVD---STDD--LLFTGSKDRTCKVWN
   WD 2 1384-1415   ------------------LGG--------HPNNV--VSVK---YCNYTSLVFTVS-TSYIKVWD
   WD 3 1471-1524   SGNAVRMWDLKRFQSTGKLTG--------HLGPV--MCLTVDQISSGQDLIITGSKDHYIKMFD
   WD 4 1525-1570   VTEGALG-----------TVSPTHNFEPPHYDGI--EALT---IQ--GDNLFSGSRDNGIKKWD
   WD 5 1578-1613   ------Q-----------QVP--------NAHKDWVCALG---VVPDHPVLLSGCRGGILKVWN
   WD 6 1617-1653   -FMPVGE-----------MKG--------HDSPI--NAIC---V--NSTHIFTAADDRTVRIWK

   WD40 Template    TGECLRT-----------LSG--------HTSGV--TSVS---FSPDGKRLVSGSEDGTIKVWD