Accession: ENSP00000376139 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000376139 (Len=344)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000376139, Len=344):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPN 80  
WD40-rpts      (________________WD 1_______________)   (____________________WD 2_______________

Query       81 KVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPG 160 
WD40-rpts      _____)(________________WD 3________________)    (__________________WD 4_________

Query      161 THTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQ 240 
WD40-rpts      _________)(___________________WD 5___________________)   (__________________WD 6

Query      241 DASLICVSSDHGTVHIFAAEDPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKF 320 
WD40-rpts      _________________)   (_________________WD 7________________)                    

Query      321 LFNPKGECIRDVYAQFLEMTDDKL 344 
WD40-rpts

7 WD40-repeats found in QUERY=ENSP00000376139 (Len=344):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  1     1-37       5.36  336.26  0.00183       22.5%     43.88
  WD 2:  Seg  4    41-86       4.72  309.60  0.00418       15.0%     38.28
  WD 3:  Seg  8    87-124      3.18  246.11  0.02963       20.0%     41.55
  WD 4:  Seg 12   129-170      4.37  294.99  0.00657       12.5%     41.32
  WD 5:  Seg 16   171-214      7.20  412.19  0.00017       22.5%     51.12
  WD 6:  Seg 20   218-258      6.97  402.60  0.00023       17.5%     55.52
  WD 7:  Seg 24   262-300      3.22  247.73  0.02819       10.0%     26.41

Multiple sequence alignment of 7 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1    1-37     MN-----LLPCN-PHG--NGLLYAGFNQDHG---CFA-------CGMENG--FRVYN
   WD 2   41-86     -L---KEKEKQE-FLE--GGVGHVEMLFRCN---YLALVGGGKKPKYPPNK-VMIWD
   WD 3   87-124    DL---KKKTVIEIEFS--TEVKAVKLRRDRI---VVV-------L---DSM-IKVFT
   WD 4  129-170    -P---HQLHVFE-TCY--NPKGLCVLCPNSNNSLLAF-------PGTHTGH-VQLVD
   WD 5  171-214    LASTEKPPVDIP-AHE--GVLSCIALNLQGT---RIA-------TASEKGTLIRIFD
   WD 6  218-258    -G---HLIQELR-RGSQAANIYCINFNQDAS---LIC-------VSSDHGT-VHIFA
   WD 7  262-300    -P---KRNKQSS-LAS--ASFLPKYFSSKWS---FSK-------FQVPSGS-PCICA

   WD40 Template    TG---ECLRTLS-GHT--SGVTSVSFSPDGK---RLV-------SGSEDGT-IKVWD