Accession: ENSP00000373312 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000373312 (Len=368)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000373312, Len=368):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MREPVLTWCVPLELLCSHPLPLSAFLKSQVKLYTYRACAGKDEMGKMVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSD 80  
WD40-rpts      (______________WD 1_____________)                   (_______________WD 2________

Query       81 RSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPH 160 
WD40-rpts      ______)(____________________WD 3____________________)     (__________________WD 

Query      161 DYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 240 
WD40-rpts      4_________________) (____________________________WD 5___________________________

Query      241 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITA 320 
WD40-rpts      )      (___________________WD 6__________________)(____________________WD 7_____

Query      321 NILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQQNEQ 368 
WD40-rpts      _______________)

7 WD40-repeats found in QUERY=ENSP00000373312 (Len=368):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  1     1-33       3.54  260.79  0.01889        7.5%     29.54
  WD 2:  Seg  7    53-87       7.98  444.30  6.4e-05       22.5%     46.99
  WD 3:  Seg 10    88-133      7.41  420.77  0.00013       27.5%     55.04
  WD 4:  Seg 14   139-179      7.73  433.91  8.8e-05       37.5%     53.85
  WD 5:  Seg 18   181-241      7.25  413.98  0.00016       42.5%     54.30
  WD 6:  Seg 22   248-290      7.46  422.70  0.00013       25.0%     52.99
  WD 7:  Seg 26   291-336      7.90  441.02  7.1e-05       20.0%     49.06

Multiple sequence alignment of 7 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1    1-33     -------------MREPVLTWCVPLELLCSHP------------------------LPLSAFLKSQVKLY-
   WD 2   53-87     T---------------VDTSHEDMIHDAQMDYY----G-----------------TRLATCSSDRSVKIFD
   WD 3   88-133    VR----N--GGQILIADLRGHEGPVWQVAWAHP--MYG-----------------NILASCSYDRKVIIWR
   WD 4  139-179    -W----E------KSHEHAGHDSSVNSVCWAPH--DYG-----------------LILACGSSDGAISLLT
   WD 5  181-241    TGEGQWE------VKKINNAHTIGCNAVSWAPA----VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWK
   WD 6  248-290    -W----K------EEQKLEAHSDWVRDVAWAPSIGLPT-----------------STIASCSQDGRVFIWT
   WD 7  291-336    CD----DASSNTWSPKLLHKFNDVVWHVSWSIT----A-----------------NILAVSGGDNKVTLWK

   WD40 Template    TG----E------CLRTLSGHTSGVTSVSFSPD----G-----------------KRLVSGSEDGTIKVWD