Accession: ENSP00000344501 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000344501 (Len=1627)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000344501, Len=1627):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGY 80  
WD40-rpts                                                                                      

Query       81 NATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLF 160 
WD40-rpts                                                                                      

Query      161 DTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVC 240 
WD40-rpts                                                                                      

Query      241 PQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATH 320 
WD40-rpts                                                                                      

Query      321 VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQMEL 400 
WD40-rpts                                                                                      

Query      401 MEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMIH 480 
WD40-rpts                                                                                      

Query      481 SYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQ 560 
WD40-rpts                                                                                      

Query      561 KLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEK 640 
WD40-rpts                                                                                      

Query      641 ANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSE 720 
WD40-rpts                                                                                      

Query      721 YEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQLKK 800 
WD40-rpts                                                                                      

Query      801 DQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQ 880 
WD40-rpts                                                                                      

Query      881 KMRIPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKR 960 
WD40-rpts                                                                                      

Query      961 REKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVINACTLTEARYL 1040
WD40-rpts                                                                                      

Query     1041 LDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDST 1120
WD40-rpts                                                                                      

Query     1121 DEDAPLNSPGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTE 1200
WD40-rpts                                                                                      

Query     1201 TSGTSAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKQSDESDSSLSEVHRGIINPFP 1280
WD40-rpts                                                                                      

Query     1281 ASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQEIMSLGGHPNNVVSVKYCNYTSLVFTVST 1360
WD40-rpts                     (_____________WD 1____________)   (________________WD 2__________

Query     1361 SYIKVWDIRDSAKCIRTLTSSGQVTLGDACSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGK 1440
WD40-rpts      ______)                                                       (_________________

Query     1441 LTGHLGPVMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQGDNLFSGSRDNGIKK 1520
WD40-rpts      _______WD 3________________________)                             (______________

Query     1521 WDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKVWNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRT 1600
WD40-rpts      _____________WD 4___________________________)   (________________WD 5___________

Query     1601 VRIWKARNLQDGQISDTGDLGEDIASN 1627
WD40-rpts      ____)

5 WD40-repeats found in QUERY=ENSP00000344501 (Len=1627):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 14  1296-1326     3.79  271.07  0.01376       35.0%     19.23
  WD 2:  Seg 16  1330-1367     5.00  321.16  0.00292       32.5%     44.80
  WD 3:  Seg 22  1423-1476     4.20  288.09  0.00814       32.5%     45.12
  WD 4:  Seg 27  1506-1565     4.82  313.70  0.00368       30.0%     40.12
  WD 5:  Seg 30  1569-1605     3.32  251.69  0.02497       15.0%     32.09

Multiple sequence alignment of 5 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1 1296-1326   ----------------------------AEG----------HTKAVLCVD---STDD--LLFTGSKDRTCKVWN
   WD 2 1330-1367   -GQEIM----------S-----------LGG----------HPNNVVSVK---YCNYTSLVFTVS-TSYIKVWD
   WD 3 1423-1476   SGNAVR----------MWDLKRFQSTGKLTG----------HLGPVMCLTVDQISSGQDLIITGSKDHYIKMFD
   WD 4 1506-1565   GDNLFSGSRDNGIKKWD-----------LTQKDLLQQVPNAHKDWVCALG---VVPDHPVLLSGCRGGILKVWN
   WD 5 1569-1605   -FMPVG----------E-----------MKG----------HDSPINAIC---V--NSTHIFTAADDRTVRIWK

   WD40 Template    TGECLR----------T-----------LSG----------HTSGVTSVS---FSPDGKRLVSGSEDGTIKVWD