Accession: ENSP00000335083 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSP00000335083 (Len=447)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSP00000335083, Len=447):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MGLSFFSKHLPIQEGQPWALKTPADIISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEF 80  
WD40-rpts      (_______________________WD 1_______________________)                      (_____

Query       81 DYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMV 160 
WD40-rpts      _______________WD 2___________________)     (_________________WD 3______________

Query      161 EVSPRRIFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVY 240 
WD40-rpts      ___)(_______________WD 4_______________)            (_________________WD 5______

Query      241 SSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQ 320 
WD40-rpts      __________)                   (________________WD 6________________)            

Query      321 VHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRR 400 
WD40-rpts        (___________________WD 7___________________)  (_________________WD 8__________

Query      401 RDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH 447 
WD40-rpts      ______)

8 WD40-repeats found in QUERY=ENSP00000335083 (Len=447):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg  1     1-52       7.20  411.88  0.00017       20.0%     44.66
  WD 2:  Seg  5    75-119      4.68  308.16  0.00437       17.5%     44.01
  WD 3:  Seg  9   125-164      6.15  368.58  0.00067       12.5%      9.75
  WD 4:  Seg 11   165-200      6.07  365.25  0.00074       25.0%     47.99
  WD 5:  Seg 16   213-251      6.02  363.53  0.00078       20.0%     38.38
  WD 6:  Seg 19   271-308      6.37  377.86  0.00050       30.0%     40.78
  WD 7:  Seg 23   323-366      5.38  336.73  0.00180        7.5%     42.85
  WD 8:  Seg 27   369-407      5.34  335.39  0.00188       12.5%     23.10

Multiple sequence alignment of 8 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1    1-52     MGLSFFSKHLPIQEGQPWAL---KTPAD----IISTVEFNH--TGELLATGDKGGRVVIFQ
   WD 2   75-119    SHEPE------------FDYLKSLEIEE----KINKIKWLPQQNAAHSLLSTNDKTIKLWK
   WD 3  125-164    KRPEG------------YNL---KDEEG----KLKDLSTVT--SLQVPVLKPMDLMVEVSP
   WD 4  165-200    ---RR------------IFA---NGHTY----HINSISVNS--DCETYMS-ADDLRINLWH
   WD 5  213-251    IKP--------------ANM---EDLTE----VITASEFHP-HHCNLFVYSSSKGSLRLCD
   WD 6  271-308    -PSNR------------SFF---SEIIS----SVSDVKFSH--SGRYMLTRD-YLTVKVWD
   WD 7  323-366    DYLRS------------KLC---SLYENDCIFDKFECAWNG--SDSVIMTGAYNNFFRMFD
   WD 8  369-407    -TKRD------------VTL---EASRE----SSKPRAVLK--PRRVCVGGKRRRDDISVD

   WD40 Template    TGECL------------RTL---SGHTS----GVTSVSFSP--DGKRLVSGSEDGTIKVWD