Accession: ENSMUSP00000113939 - WDRR: WD40 Repeat Recognition

Input parameters:

  Query = ENSMUSP00000113939 (Len=1934)
  Tmplt = WD40-str (Len=40)
  Method = bdp  Gap-open = 50  Gap-extend = 3
  Database = /home/pub/blastdb/nr90  E-value = 0.001  Iteration = 3

Query sequence (ENSMUSP00000113939, Len=1934):

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Query        1 MAQGSRRRKVVLTAGSEGWSPSSGPDMEELLRSVERDLNIDARQLALAPGGTHVVALVSTRWLASLRERRLGPCPRAEGL 80  
WD40-rpts                                                                                      

Query       81 GEAEVRTLLQRSVQRLPPGWTRVEVHGLRKRRLSYPLGGGVPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPY 160 
WD40-rpts                                                                                      

Query      161 SHSTAPSALPALDSIRQALQRVYGCTFLPVGESIPCLSNVRDGPCPSRGSPACPSLLRAEALLESPEMLYVVHPYVQFSL 240 
WD40-rpts                                                                                      

Query      241 HDVVTFSPAKLTNSQAKVLFLLFRVLRAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEGSEEKN 320 
WD40-rpts                                                                                      

Query      321 GTGIKSEKEGEGRTECPTCQKELRGLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPYGRFRDLRKS 400 
WD40-rpts                                                                                      

Query      401 KFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPATMER 480 
WD40-rpts                                                                                      

Query      481 MQTWTPDECIPEFYTDPSIFCSIHPDMPDLDVPAWCSSNQEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEK 560 
WD40-rpts                                                                                      

Query      561 NVCLHLVDAHTHLTSYGVVQLFDQPHPQRLAGSPALAPEPPLIPRLLVQPIREATGQEDISGQLINGAGRLVVEATPCET 640 
WD40-rpts                                                                                      

Query      641 GWTRDRPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQASPGLLSFSAPSGSRPGRRSKAAGLDPGEGEEGKIVLPEG 720 
WD40-rpts                                                                                      

Query      721 FSPIQALEELEKVGNFLAKGLGSQLEEPEKPHAQPPVHLQSLFHRDMQVLGVLLAEMVFATRVRILQPDAPLWVRFEAVR 800 
WD40-rpts                                                                                      

Query      801 GLCIRHSKDIPVSLQPVLDTLLQLSGPKSPMVSKKGKLDPLFEYRPVSQGLPPPSPAQLLSPFSSVVPFPPYFPALHKFI 880 
WD40-rpts                                                                                      

Query      881 LLYQARRVEDEVQGRELAFALWQQLGAVLNDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLK 960 
WD40-rpts                                                                                      

Query      961 PLIGAYESPCRLHGRFYLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVEASQEEGKGLVGTTEDEESELPVSGPGSC 1040
WD40-rpts                                                                                      

Query     1041 AFGEEIQMDGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAESPQPQEAEAVSLGQLSDKSSTSEASQGEERG 1120
WD40-rpts                                                                                      

Query     1121 GDDGGAPADKNSVKSGDSSQDLKQSEGSEEEEEEEGCVVLEEDQEDEVTGTSELTLSDTMLSMETVVAPGDGRDREEEEE 1200
WD40-rpts                                                                                      

Query     1201 PLTEQTEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSDDTPPLNAGNIYQKRPVL 1280
WD40-rpts                                                                                      

Query     1281 GDIVSGPVLSCLLHIAYLYGEPVLTYQYLPYISYLVAPGSNSNPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPR 1360
WD40-rpts                                                                                      

Query     1361 ISHEVLLPVLGFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSHLHELRQQDLPLDP 1440
WD40-rpts                                                                                      

Query     1441 KGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAGLYLESMSPSSRN 1520
WD40-rpts                                                             (__________________WD 1__

Query     1521 PASMEPTMASAGPEWDPQSGSCLQDDGHSGTFGSVLVGNRIQIPDSQPQSPGPLGSLSGVGSSGGLSNRNEDNALKRELP 1600
WD40-rpts      _______________)                                           (_______________WD 2_

Query     1601 RSAHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWPLYNYGDGTNET 1680
WD40-rpts      ______________)               (_________________WD 3________________)          (

Query     1681 ASRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVDPSDSRVPLTAVAVMPAPHTSITMASSDSTLRFV 1760
WD40-rpts      ________________WD 4_______________)   (__________________WD 5__________________

Query     1761 DCRKPGLQHEFRLGGGLNPGLVRSLAVSPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLISSSS 1840
WD40-rpts      )       (_________________WD 6________________)   (________________WD 7_________

Query     1841 DHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRH 1920
WD40-rpts      _______)                                   (_______________________WD 8_________

Query     1921 LLLGSDNGIIRLLA 1934
WD40-rpts      _____________)

8 WD40-repeats found in QUERY=ENSMUSP00000113939 (Len=1934):

(Red - Z-score>4.0)

  Rpts  Segment   Boundary  Z-score   Score  P-value  Identities  SS-score
  WD 1:  Seg 20  1496-1536     5.47  340.73  0.00159       22.5%     20.91
  WD 2:  Seg 24  1580-1615     5.70  350.04  0.00119       12.5%     32.12
  WD 3:  Seg 26  1631-1669     7.77  435.50  8.4e-05       30.0%     46.40
  WD 4:  Seg 29  1680-1716     5.24  331.04  0.00215       25.0%     42.10
  WD 5:  Seg 32  1720-1761     5.61  346.40  0.00134       32.5%     53.69
  WD 6:  Seg 36  1769-1807     6.59  386.84  0.00038       25.0%     48.52
  WD 7:  Seg 40  1811-1848     6.98  402.96  0.00023       27.5%     52.70
  WD 8:  Seg 47  1884-1934     5.79  353.76  0.00106       25.0%     37.78

Multiple sequence alignment of 8 WD40-repeats:

(BLUE - beta-strands, RED - alpha-helices, predicted by PSIPRED)

   WD 1 1496-1536   -IIP-----------NHELVGELAGL--YLESMSPSSR-NPASMEPTMASAGPEWD
   WD 2 1580-1615   VG---------------SSGGLSNRN--EDNALKRELP-RSAH--GLSGNWLAYWQ
   WD 3 1631-1669   -QIR-----------LQSFPGHTGAV--KCVAALSSED-FFLS--GSKDRTVRLWP
   WD 4 1680-1716   -TAS-----------RLIYAQHRKSV--FYVGQLEAPQ-YVVS--C--DGAVHVWD
   WD 5 1720-1761   -GKT-----------LRTVDPSDSRVPLTAVAVMPAPHTSITM--ASSDSTLRFVD
   WD 6 1769-1807   -HEF-----------RLGGGLNPGLV--RSLAVSPSGR-SVVA--GFSSGFMVLLD
   WD 7 1811-1848   -GLV-----------LRGWPAHEGDI--LQIK-AVEGS-VLIS--SSSDHSLTVWK
   WD 8 1884-1934   IGVCSLLEPPSQATTKLSSENFRGTL--TSLALLPTKR-HLLL--GSDNGIIRLLA

   WD40 Template    TGEC-----------LRTLSGHTSGV--TSVSFSPDGK-RLVS--GSEDGTIKVWD