Gene type: Transcription factor Metabolic gene Others DE type: Up Down Slightly_up Slightly_down Mixeded Others

GO Enrichment Analysis of Co-expressed Genes with

AT5G59770

GO-BP
GO-MF
GO-CC
RankGO TermAdjusted P value
1GO:0071244: cellular response to carbon dioxide0.00E+00
2GO:0018293: protein-FAD linkage0.00E+00
3GO:0034553: mitochondrial respiratory chain complex II assembly0.00E+00
4GO:0032780: negative regulation of ATPase activity0.00E+00
5GO:0010336: gibberellic acid homeostasis0.00E+00
6GO:0098586: cellular response to virus0.00E+00
7GO:0019379: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)0.00E+00
8GO:0090470: shoot organ boundary specification0.00E+00
9GO:0017009: protein-phycocyanobilin linkage0.00E+00
10GO:0046294: formaldehyde catabolic process0.00E+00
11GO:0010477: response to sulfur dioxide0.00E+00
12GO:0009661: chromoplast organization0.00E+00
13GO:0009902: chloroplast relocation1.04E-06
14GO:0055114: oxidation-reduction process1.57E-06
15GO:0010100: negative regulation of photomorphogenesis2.57E-05
16GO:0071483: cellular response to blue light1.03E-04
17GO:0016120: carotene biosynthetic process1.59E-04
18GO:0010236: plastoquinone biosynthetic process1.59E-04
19GO:0015995: chlorophyll biosynthetic process1.88E-04
20GO:0010190: cytochrome b6f complex assembly2.27E-04
21GO:0009903: chloroplast avoidance movement3.06E-04
22GO:0071461: cellular response to redox state4.18E-04
23GO:0048438: floral whorl development4.18E-04
24GO:0080065: 4-alpha-methyl-delta7-sterol oxidation4.18E-04
25GO:0010362: negative regulation of anion channel activity by blue light4.18E-04
26GO:0046467: membrane lipid biosynthetic process4.18E-04
27GO:0010036: response to boron-containing substance4.18E-04
28GO:1902265: abscisic acid homeostasis4.18E-04
29GO:0007623: circadian rhythm6.66E-04
30GO:0080183: response to photooxidative stress9.05E-04
31GO:0043100: pyrimidine nucleobase salvage9.05E-04
32GO:0042754: negative regulation of circadian rhythm9.05E-04
33GO:0010275: NAD(P)H dehydrogenase complex assembly9.05E-04
34GO:0010343: singlet oxygen-mediated programmed cell death9.05E-04
35GO:0080005: photosystem stoichiometry adjustment9.05E-04
36GO:0046741: transport of virus in host, tissue to tissue9.05E-04
37GO:0019388: galactose catabolic process9.05E-04
38GO:2000030: regulation of response to red or far red light9.05E-04
39GO:0007154: cell communication9.05E-04
40GO:0000256: allantoin catabolic process9.05E-04
41GO:0010220: positive regulation of vernalization response9.05E-04
42GO:0006898: receptor-mediated endocytosis9.05E-04
43GO:1904143: positive regulation of carotenoid biosynthetic process9.05E-04
44GO:0009970: cellular response to sulfate starvation9.91E-04
45GO:0000103: sulfate assimilation9.91E-04
46GO:0006790: sulfur compound metabolic process1.30E-03
47GO:0009658: chloroplast organization1.43E-03
48GO:0016570: histone modification1.47E-03
49GO:0031022: nuclear migration along microfilament1.47E-03
50GO:0019419: sulfate reduction1.47E-03
51GO:0010136: ureide catabolic process1.47E-03
52GO:1901562: response to paraquat1.47E-03
53GO:0006013: mannose metabolic process1.47E-03
54GO:0009150: purine ribonucleotide metabolic process1.47E-03
55GO:0006696: ergosterol biosynthetic process1.47E-03
56GO:0071836: nectar secretion1.47E-03
57GO:0044375: regulation of peroxisome size1.47E-03
58GO:0005986: sucrose biosynthetic process1.48E-03
59GO:2001141: regulation of RNA biosynthetic process2.13E-03
60GO:0046713: borate transport2.13E-03
61GO:0010371: regulation of gibberellin biosynthetic process2.13E-03
62GO:0071484: cellular response to light intensity2.13E-03
63GO:0009647: skotomorphogenesis2.13E-03
64GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity2.13E-03
65GO:0006145: purine nucleobase catabolic process2.13E-03
66GO:0009590: detection of gravity2.13E-03
67GO:0050482: arachidonic acid secretion2.13E-03
68GO:0010148: transpiration2.13E-03
69GO:0009963: positive regulation of flavonoid biosynthetic process2.13E-03
70GO:0043572: plastid fission2.13E-03
71GO:0006099: tricarboxylic acid cycle2.31E-03
72GO:0008299: isoprenoid biosynthetic process2.55E-03
73GO:0070534: protein K63-linked ubiquitination2.86E-03
74GO:0071585: detoxification of cadmium ion2.86E-03
75GO:0015994: chlorophyll metabolic process2.86E-03
76GO:0009649: entrainment of circadian clock2.86E-03
77GO:0034613: cellular protein localization2.86E-03
78GO:0010021: amylopectin biosynthetic process2.86E-03
79GO:0009640: photomorphogenesis3.02E-03
80GO:0016226: iron-sulfur cluster assembly3.07E-03
81GO:0035434: copper ion transmembrane transport3.66E-03
82GO:0000304: response to singlet oxygen3.66E-03
83GO:0010117: photoprotection3.66E-03
84GO:0046283: anthocyanin-containing compound metabolic process3.66E-03
85GO:0009904: chloroplast accumulation movement3.66E-03
86GO:0006508: proteolysis3.81E-03
87GO:0016117: carotenoid biosynthetic process3.95E-03
88GO:0006121: mitochondrial electron transport, succinate to ubiquinone4.52E-03
89GO:0006301: postreplication repair4.52E-03
90GO:0010304: PSII associated light-harvesting complex II catabolic process4.52E-03
91GO:0006555: methionine metabolic process4.52E-03
92GO:0070814: hydrogen sulfide biosynthetic process4.52E-03
93GO:1902456: regulation of stomatal opening4.52E-03
94GO:0033365: protein localization to organelle4.52E-03
95GO:0000060: protein import into nucleus, translocation4.52E-03
96GO:0019243: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione4.52E-03
97GO:0046686: response to cadmium ion4.59E-03
98GO:0019252: starch biosynthetic process5.31E-03
99GO:0010019: chloroplast-nucleus signaling pathway5.46E-03
100GO:0009648: photoperiodism5.46E-03
101GO:0010077: maintenance of inflorescence meristem identity5.46E-03
102GO:0019509: L-methionine salvage from methylthioadenosine5.46E-03
103GO:0010076: maintenance of floral meristem identity5.46E-03
104GO:0010189: vitamin E biosynthetic process5.46E-03
105GO:0048510: regulation of timing of transition from vegetative to reproductive phase5.69E-03
106GO:0010038: response to metal ion6.45E-03
107GO:0050790: regulation of catalytic activity6.45E-03
108GO:0006368: transcription elongation from RNA polymerase II promoter6.45E-03
109GO:0070370: cellular heat acclimation6.45E-03
110GO:0000105: histidine biosynthetic process7.50E-03
111GO:0009231: riboflavin biosynthetic process7.50E-03
112GO:0006102: isocitrate metabolic process7.50E-03
113GO:0016559: peroxisome fission7.50E-03
114GO:0006644: phospholipid metabolic process7.50E-03
115GO:0048564: photosystem I assembly7.50E-03
116GO:0030091: protein repair7.50E-03
117GO:0005978: glycogen biosynthetic process7.50E-03
118GO:0009787: regulation of abscisic acid-activated signaling pathway7.50E-03
119GO:0050821: protein stabilization7.50E-03
120GO:0071482: cellular response to light stimulus8.61E-03
121GO:0015996: chlorophyll catabolic process8.61E-03
122GO:0048574: long-day photoperiodism, flowering8.61E-03
123GO:0042128: nitrate assimilation9.22E-03
124GO:0009821: alkaloid biosynthetic process9.78E-03
125GO:0034765: regulation of ion transmembrane transport9.78E-03
126GO:0046916: cellular transition metal ion homeostasis9.78E-03
127GO:0018298: protein-chromophore linkage1.08E-02
128GO:0051453: regulation of intracellular pH1.10E-02
129GO:0009638: phototropism1.10E-02
130GO:0045454: cell redox homeostasis1.10E-02
131GO:0009098: leucine biosynthetic process1.10E-02
132GO:0045036: protein targeting to chloroplast1.23E-02
133GO:0009641: shade avoidance1.23E-02
134GO:0051555: flavonol biosynthetic process1.23E-02
135GO:0006995: cellular response to nitrogen starvation1.23E-02
136GO:0048229: gametophyte development1.36E-02
137GO:0043085: positive regulation of catalytic activity1.36E-02
138GO:0009773: photosynthetic electron transport in photosystem I1.36E-02
139GO:0006879: cellular iron ion homeostasis1.36E-02
140GO:0008285: negative regulation of cell proliferation1.36E-02
141GO:0006352: DNA-templated transcription, initiation1.36E-02
142GO:0000272: polysaccharide catabolic process1.36E-02
143GO:0018119: peptidyl-cysteine S-nitrosylation1.36E-02
144GO:0016485: protein processing1.36E-02
145GO:0009637: response to blue light1.37E-02
146GO:0034599: cellular response to oxidative stress1.43E-02
147GO:0010228: vegetative to reproductive phase transition of meristem1.48E-02
148GO:0010582: floral meristem determinacy1.50E-02
149GO:0009739: response to gibberellin1.61E-02
150GO:0009718: anthocyanin-containing compound biosynthetic process1.64E-02
151GO:0009767: photosynthetic electron transport chain1.64E-02
152GO:0030048: actin filament-based movement1.64E-02
153GO:0006108: malate metabolic process1.64E-02
154GO:0006006: glucose metabolic process1.64E-02
155GO:0010207: photosystem II assembly1.79E-02
156GO:0010020: chloroplast fission1.79E-02
157GO:0007015: actin filament organization1.79E-02
158GO:0007031: peroxisome organization1.94E-02
159GO:0006071: glycerol metabolic process2.09E-02
160GO:0019344: cysteine biosynthetic process2.25E-02
161GO:0051017: actin filament bundle assembly2.25E-02
162GO:0009585: red, far-red light phototransduction2.39E-02
163GO:0010073: meristem maintenance2.42E-02
164GO:0006825: copper ion transport2.42E-02
165GO:0051302: regulation of cell division2.42E-02
166GO:0051603: proteolysis involved in cellular protein catabolic process2.48E-02
167GO:0031408: oxylipin biosynthetic process2.59E-02
168GO:0006366: transcription from RNA polymerase II promoter2.59E-02
169GO:0010227: floral organ abscission2.94E-02
170GO:0006012: galactose metabolic process2.94E-02
171GO:0009693: ethylene biosynthetic process2.94E-02
172GO:0009411: response to UV2.94E-02
173GO:0040007: growth2.94E-02
174GO:0006817: phosphate ion transport3.11E-02
175GO:0010118: stomatal movement3.49E-02
176GO:0042631: cellular response to water deprivation3.49E-02
177GO:0080022: primary root development3.49E-02
178GO:0042335: cuticle development3.49E-02
179GO:0042391: regulation of membrane potential3.49E-02
180GO:0010182: sugar mediated signaling pathway3.68E-02
181GO:0009741: response to brassinosteroid3.68E-02
182GO:0006520: cellular amino acid metabolic process3.68E-02
183GO:0006662: glycerol ether metabolic process3.68E-02
184GO:0015979: photosynthesis3.74E-02
185GO:0035556: intracellular signal transduction3.82E-02
186GO:0042752: regulation of circadian rhythm3.87E-02
187GO:0009791: post-embryonic development4.07E-02
188GO:0000302: response to reactive oxygen species4.27E-02
189GO:0019761: glucosinolate biosynthetic process4.48E-02
190GO:0009058: biosynthetic process4.48E-02
191GO:0030163: protein catabolic process4.68E-02
192GO:0009567: double fertilization forming a zygote and endosperm4.89E-02
193GO:0006464: cellular protein modification process4.89E-02
RankGO TermAdjusted P value
1GO:0047501: (+)-neomenthol dehydrogenase activity0.00E+00
2GO:0042030: ATPase inhibitor activity0.00E+00
3GO:0035798: 2-alkenal reductase (NADP+) activity0.00E+00
4GO:0016767: geranylgeranyl-diphosphate geranylgeranyltransferase activity0.00E+00
5GO:0050342: tocopherol O-methyltransferase activity0.00E+00
6GO:0045436: lycopene beta cyclase activity0.00E+00
7GO:0047504: (-)-menthol dehydrogenase activity0.00E+00
8GO:0018738: S-formylglutathione hydrolase activity0.00E+00
9GO:0009673: low-affinity phosphate transmembrane transporter activity0.00E+00
10GO:0050486: intramolecular transferase activity, transferring hydroxy groups0.00E+00
11GO:0004399: histidinol dehydrogenase activity0.00E+00
12GO:0015205: nucleobase transmembrane transporter activity0.00E+00
13GO:0047230: flavonol-3-O-glucoside L-rhamnosyltransferase activity0.00E+00
14GO:0046905: phytoene synthase activity0.00E+00
15GO:0008482: sulfite oxidase activity0.00E+00
16GO:0004848: ureidoglycolate hydrolase activity7.47E-08
17GO:0016491: oxidoreductase activity4.55E-06
18GO:0050347: trans-octaprenyltranstransferase activity7.79E-06
19GO:0052924: all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity7.79E-06
20GO:0004180: carboxypeptidase activity2.69E-05
21GO:0003913: DNA photolyase activity2.69E-05
22GO:0000989: transcription factor activity, transcription factor binding3.50E-05
23GO:0016851: magnesium chelatase activity5.86E-05
24GO:0008106: alcohol dehydrogenase (NADP+) activity5.86E-05
25GO:0008236: serine-type peptidase activity2.06E-04
26GO:0042802: identical protein binding2.11E-04
27GO:0004328: formamidase activity4.18E-04
28GO:0030941: chloroplast targeting sequence binding4.18E-04
29GO:0051741: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity4.18E-04
30GO:0008793: aromatic-amino-acid:2-oxoglutarate aminotransferase activity4.18E-04
31GO:0016784: 3-mercaptopyruvate sulfurtransferase activity4.18E-04
32GO:0035671: enone reductase activity4.18E-04
33GO:0046906: tetrapyrrole binding4.18E-04
34GO:0004719: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity4.18E-04
35GO:0080139: borate efflux transmembrane transporter activity4.18E-04
36GO:0016783: sulfurtransferase activity4.18E-04
37GO:0051996: squalene synthase activity4.18E-04
38GO:0016868: intramolecular transferase activity, phosphotransferases9.05E-04
39GO:0043425: bHLH transcription factor binding9.05E-04
40GO:0033741: adenylyl-sulfate reductase (glutathione) activity9.05E-04
41GO:0008686: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity9.05E-04
42GO:0033201: alpha-1,4-glucan synthase activity9.05E-04
43GO:0015173: aromatic amino acid transmembrane transporter activity9.05E-04
44GO:0009973: adenylyl-sulfate reductase activity9.05E-04
45GO:1990269: RNA polymerase II C-terminal domain phosphoserine binding9.05E-04
46GO:0004604: phosphoadenylyl-sulfate reductase (thioredoxin) activity9.05E-04
47GO:0004614: phosphoglucomutase activity9.05E-04
48GO:0004450: isocitrate dehydrogenase (NADP+) activity9.05E-04
49GO:0004046: aminoacylase activity9.05E-04
50GO:0004310: farnesyl-diphosphate farnesyltransferase activity9.05E-04
51GO:0003988: acetyl-CoA C-acyltransferase activity9.05E-04
52GO:0008237: metallopeptidase activity9.98E-04
53GO:0001076: transcription factor activity, RNA polymerase II transcription factor binding1.47E-03
54GO:0010309: acireductone dioxygenase [iron(II)-requiring] activity1.47E-03
55GO:0010277: chlorophyllide a oxygenase [overall] activity1.47E-03
56GO:0046524: sucrose-phosphate synthase activity1.47E-03
57GO:0004373: glycogen (starch) synthase activity1.47E-03
58GO:0003955: NAD(P)H dehydrogenase (quinone) activity1.47E-03
59GO:0050307: sucrose-phosphate phosphatase activity1.47E-03
60GO:0032947: protein complex scaffold1.47E-03
61GO:0004557: alpha-galactosidase activity1.47E-03
62GO:0003861: 3-isopropylmalate dehydratase activity1.47E-03
63GO:0003935: GTP cyclohydrolase II activity1.47E-03
64GO:0004781: sulfate adenylyltransferase (ATP) activity1.47E-03
65GO:0004096: catalase activity1.47E-03
66GO:0009882: blue light photoreceptor activity2.13E-03
67GO:0047627: adenylylsulfatase activity2.13E-03
68GO:0004742: dihydrolipoyllysine-residue acetyltransferase activity2.13E-03
69GO:0000254: C-4 methylsterol oxidase activity2.13E-03
70GO:0015175: neutral amino acid transmembrane transporter activity2.13E-03
71GO:0004792: thiosulfate sulfurtransferase activity2.13E-03
72GO:0004416: hydroxyacylglutathione hydrolase activity2.13E-03
73GO:0016811: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides2.13E-03
74GO:0046715: borate transmembrane transporter activity2.13E-03
75GO:0004176: ATP-dependent peptidase activity2.80E-03
76GO:0001053: plastid sigma factor activity2.86E-03
77GO:0051861: glycolipid binding2.86E-03
78GO:0016987: sigma factor activity2.86E-03
79GO:0009011: starch synthase activity2.86E-03
80GO:0030151: molybdenum ion binding3.66E-03
81GO:0015301: anion:anion antiporter activity3.66E-03
82GO:0008177: succinate dehydrogenase (ubiquinone) activity3.66E-03
83GO:0004623: phospholipase A2 activity3.66E-03
84GO:0005452: inorganic anion exchanger activity3.66E-03
85GO:0004709: MAP kinase kinase kinase activity4.52E-03
86GO:0004069: L-aspartate:2-oxoglutarate aminotransferase activity4.52E-03
87GO:0003860: 3-hydroxyisobutyryl-CoA hydrolase activity4.52E-03
88GO:0000293: ferric-chelate reductase activity4.52E-03
89GO:0010181: FMN binding4.95E-03
90GO:0004559: alpha-mannosidase activity5.46E-03
91GO:0016157: sucrose synthase activity5.46E-03
92GO:0005242: inward rectifier potassium channel activity5.46E-03
93GO:0016161: beta-amylase activity5.46E-03
94GO:0030060: L-malate dehydrogenase activity5.46E-03
95GO:0048038: quinone binding5.69E-03
96GO:0016621: cinnamoyl-CoA reductase activity6.45E-03
97GO:0009881: photoreceptor activity6.45E-03
98GO:0019899: enzyme binding6.45E-03
99GO:0016671: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor6.48E-03
100GO:0016847: 1-aminocyclopropane-1-carboxylate synthase activity7.50E-03
101GO:0004034: aldose 1-epimerase activity7.50E-03
102GO:0046914: transition metal ion binding8.61E-03
103GO:0005375: copper ion transmembrane transporter activity8.61E-03
104GO:0016705: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen9.57E-03
105GO:0008889: glycerophosphodiester phosphodiesterase activity9.78E-03
106GO:0071949: FAD binding9.78E-03
107GO:0016844: strictosidine synthase activity1.10E-02
108GO:0004222: metalloendopeptidase activity1.19E-02
109GO:0005506: iron ion binding1.33E-02
110GO:0019904: protein domain specific binding1.36E-02
111GO:0031072: heat shock protein binding1.64E-02
112GO:0000155: phosphorelay sensor kinase activity1.64E-02
113GO:0015266: protein channel activity1.64E-02
114GO:0015662: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism1.64E-02
115GO:0005315: inorganic phosphate transmembrane transporter activity1.64E-02
116GO:0004185: serine-type carboxypeptidase activity1.77E-02
117GO:0042973: glucan endo-1,3-beta-D-glucosidase activity1.79E-02
118GO:0051287: NAD binding2.15E-02
119GO:0051536: iron-sulfur cluster binding2.25E-02
120GO:0001046: core promoter sequence-specific DNA binding2.25E-02
121GO:0000287: magnesium ion binding2.37E-02
122GO:0016788: hydrolase activity, acting on ester bonds2.48E-02
123GO:0005515: protein binding2.52E-02
124GO:0004672: protein kinase activity2.84E-02
125GO:0016887: ATPase activity2.90E-02
126GO:0016747: transferase activity, transferring acyl groups other than amino-acyl groups2.92E-02
127GO:0047134: protein-disulfide reductase activity3.30E-02
128GO:0005249: voltage-gated potassium channel activity3.49E-02
129GO:0030551: cyclic nucleotide binding3.49E-02
130GO:0015035: protein disulfide oxidoreductase activity3.50E-02
131GO:0004527: exonuclease activity3.68E-02
132GO:0016538: cyclin-dependent protein serine/threonine kinase regulator activity3.68E-02
133GO:0008080: N-acetyltransferase activity3.68E-02
134GO:0004791: thioredoxin-disulfide reductase activity3.87E-02
135GO:0016853: isomerase activity3.87E-02
136GO:0050662: coenzyme binding3.87E-02
137GO:0004197: cysteine-type endopeptidase activity4.48E-02
138GO:0016829: lyase activity4.59E-02
139GO:0016791: phosphatase activity4.89E-02
RankGO TermAdjusted P value
1GO:0031313: extrinsic component of endosome membrane0.00E+00
2GO:0097708: intracellular vesicle0.00E+00
3GO:0009507: chloroplast8.12E-21
4GO:0009535: chloroplast thylakoid membrane2.92E-06
5GO:0031969: chloroplast membrane1.48E-05
6GO:0005777: peroxisome1.88E-05
7GO:0031972: chloroplast intermembrane space4.18E-04
8GO:0043674: columella4.18E-04
9GO:0000152: nuclear ubiquitin ligase complex4.18E-04
10GO:0031234: extrinsic component of cytoplasmic side of plasma membrane4.18E-04
11GO:0009570: chloroplast stroma5.24E-04
12GO:0005773: vacuole5.85E-04
13GO:0045254: pyruvate dehydrogenase complex9.05E-04
14GO:0010319: stromule9.98E-04
15GO:0016328: lateral plasma membrane1.47E-03
16GO:0010007: magnesium chelatase complex1.47E-03
17GO:0005764: lysosome1.67E-03
18GO:0042651: thylakoid membrane2.55E-03
19GO:0009527: plastid outer membrane2.86E-03
20GO:0031372: UBC13-MMS2 complex2.86E-03
21GO:0016593: Cdc73/Paf1 complex2.86E-03
22GO:0009526: plastid envelope2.86E-03
23GO:0005747: mitochondrial respiratory chain complex I5.71E-03
24GO:0031359: integral component of chloroplast outer membrane6.45E-03
25GO:0009706: chloroplast inner membrane6.94E-03
26GO:0009536: plastid7.40E-03
27GO:0009501: amyloplast7.50E-03
28GO:0031982: vesicle7.50E-03
29GO:0009514: glyoxysome8.61E-03
30GO:0005779: integral component of peroxisomal membrane8.61E-03
31GO:0010287: plastoglobule8.63E-03
32GO:0010598: NAD(P)H dehydrogenase complex (plastoquinone)9.78E-03
33GO:0009707: chloroplast outer membrane1.08E-02
34GO:0016604: nuclear body1.10E-02
35GO:0005759: mitochondrial matrix1.24E-02
36GO:0005884: actin filament1.36E-02
37GO:0009532: plastid stroma2.59E-02
38GO:0005739: mitochondrion2.78E-02
39GO:0005744: mitochondrial inner membrane presequence translocase complex3.11E-02
40GO:0009543: chloroplast thylakoid lumen4.25E-02
41GO:0009534: chloroplast thylakoid4.63E-02
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Gene type



Gene DE type