Gene type: Transcription factor Metabolic gene Others DE type: Up Down Slightly_up Slightly_down Mixeded Others

GO Enrichment Analysis of Co-expressed Genes with

AT2G40100

GO-BP
GO-MF
GO-CC
RankGO TermAdjusted P value
1GO:0015843: methylammonium transport0.00E+00
2GO:0009722: detection of cytokinin stimulus0.00E+00
3GO:0071345: cellular response to cytokine stimulus0.00E+00
4GO:0015822: ornithine transport0.00E+00
5GO:0042178: xenobiotic catabolic process0.00E+00
6GO:0010336: gibberellic acid homeostasis0.00E+00
7GO:0010423: negative regulation of brassinosteroid biosynthetic process0.00E+00
8GO:0080094: response to trehalose-6-phosphate0.00E+00
9GO:0009715: chalcone biosynthetic process0.00E+00
10GO:0052889: 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene0.00E+00
11GO:0090393: sepal giant cell development0.00E+00
12GO:0019265: glycine biosynthetic process, by transamination of glyoxylate0.00E+00
13GO:0071629: ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome0.00E+00
14GO:0080167: response to karrikin7.05E-07
15GO:0071555: cell wall organization4.01E-05
16GO:0009813: flavonoid biosynthetic process5.65E-05
17GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity1.29E-04
18GO:0010076: maintenance of floral meristem identity1.29E-04
19GO:0052543: callose deposition in cell wall2.16E-04
20GO:0006805: xenobiotic metabolic process2.39E-04
21GO:0019510: S-adenosylhomocysteine catabolic process2.39E-04
22GO:0006169: adenosine salvage2.39E-04
23GO:1901349: glucosinolate transport2.39E-04
24GO:1902265: abscisic acid homeostasis2.39E-04
25GO:0090449: phloem glucosinolate loading2.39E-04
26GO:0071370: cellular response to gibberellin stimulus2.39E-04
27GO:0006659: phosphatidylserine biosynthetic process2.39E-04
28GO:0019605: butyrate metabolic process2.39E-04
29GO:0006083: acetate metabolic process2.39E-04
30GO:0048438: floral whorl development2.39E-04
31GO:0000066: mitochondrial ornithine transport2.39E-04
32GO:0051555: flavonol biosynthetic process4.48E-04
33GO:0009698: phenylpropanoid metabolic process5.19E-04
34GO:0030388: fructose 1,6-bisphosphate metabolic process5.29E-04
35GO:0006152: purine nucleoside catabolic process5.29E-04
36GO:0009629: response to gravity5.29E-04
37GO:0033353: S-adenosylmethionine cycle5.29E-04
38GO:0007154: cell communication5.29E-04
39GO:0010220: positive regulation of vernalization response5.29E-04
40GO:0015712: hexose phosphate transport5.29E-04
41GO:0006810: transport5.38E-04
42GO:0006011: UDP-glucose metabolic process8.60E-04
43GO:0031022: nuclear migration along microfilament8.60E-04
44GO:0006000: fructose metabolic process8.60E-04
45GO:0035436: triose phosphate transmembrane transport8.60E-04
46GO:0010253: UDP-rhamnose biosynthetic process8.60E-04
47GO:0044375: regulation of peroxisome size8.60E-04
48GO:0006651: diacylglycerol biosynthetic process8.60E-04
49GO:0005977: glycogen metabolic process8.60E-04
50GO:0015696: ammonium transport1.23E-03
51GO:0009963: positive regulation of flavonoid biosynthetic process1.23E-03
52GO:0042823: pyridoxal phosphate biosynthetic process1.23E-03
53GO:0032877: positive regulation of DNA endoreduplication1.23E-03
54GO:0010258: NADH dehydrogenase complex (plastoquinone) assembly1.23E-03
55GO:0006730: one-carbon metabolic process1.36E-03
56GO:0009411: response to UV1.48E-03
57GO:0019722: calcium-mediated signaling1.61E-03
58GO:0019676: ammonia assimilation cycle1.64E-03
59GO:0048442: sepal development1.64E-03
60GO:0019464: glycine decarboxylation via glycine cleavage system1.64E-03
61GO:0072488: ammonium transmembrane transport1.64E-03
62GO:0006546: glycine catabolic process1.64E-03
63GO:0006021: inositol biosynthetic process1.64E-03
64GO:0009902: chloroplast relocation1.64E-03
65GO:0015713: phosphoglycerate transport1.64E-03
66GO:0009694: jasmonic acid metabolic process1.64E-03
67GO:0006542: glutamine biosynthetic process1.64E-03
68GO:0006857: oligopeptide transport1.69E-03
69GO:0016117: carotenoid biosynthetic process1.75E-03
70GO:0045489: pectin biosynthetic process2.03E-03
71GO:0044209: AMP salvage2.09E-03
72GO:0016094: polyprenol biosynthetic process2.09E-03
73GO:0019408: dolichol biosynthetic process2.09E-03
74GO:0016120: carotene biosynthetic process2.09E-03
75GO:0006097: glyoxylate cycle2.09E-03
76GO:0048510: regulation of timing of transition from vegetative to reproductive phase2.50E-03
77GO:0010264: myo-inositol hexakisphosphate biosynthetic process2.57E-03
78GO:0010315: auxin efflux2.57E-03
79GO:0006559: L-phenylalanine catabolic process2.57E-03
80GO:0009635: response to herbicide2.57E-03
81GO:0000060: protein import into nucleus, translocation2.57E-03
82GO:0010942: positive regulation of cell death2.57E-03
83GO:0010304: PSII associated light-harvesting complex II catabolic process2.57E-03
84GO:0010077: maintenance of inflorescence meristem identity3.09E-03
85GO:0045926: negative regulation of growth3.09E-03
86GO:0017148: negative regulation of translation3.09E-03
87GO:0009903: chloroplast avoidance movement3.09E-03
88GO:0007267: cell-cell signaling3.21E-03
89GO:0042128: nitrate assimilation4.03E-03
90GO:0016559: peroxisome fission4.23E-03
91GO:0007155: cell adhesion4.23E-03
92GO:0009787: regulation of abscisic acid-activated signaling pathway4.23E-03
93GO:0031540: regulation of anthocyanin biosynthetic process4.23E-03
94GO:0048573: photoperiodism, flowering4.25E-03
95GO:0006002: fructose 6-phosphate metabolic process4.84E-03
96GO:0022900: electron transport chain4.84E-03
97GO:0008152: metabolic process4.97E-03
98GO:0010119: regulation of stomatal movement5.43E-03
99GO:0009056: catabolic process5.48E-03
100GO:0009853: photorespiration5.96E-03
101GO:0016051: carbohydrate biosynthetic process5.96E-03
102GO:0005975: carbohydrate metabolic process6.09E-03
103GO:0010192: mucilage biosynthetic process6.85E-03
104GO:0048441: petal development6.85E-03
105GO:0000272: polysaccharide catabolic process7.58E-03
106GO:0009926: auxin polar transport7.68E-03
107GO:0042546: cell wall biogenesis7.99E-03
108GO:0015706: nitrate transport8.33E-03
109GO:0016024: CDP-diacylglycerol biosynthetic process8.33E-03
110GO:0010582: floral meristem determinacy8.33E-03
111GO:0016925: protein sumoylation8.33E-03
112GO:0009636: response to toxic substance8.64E-03
113GO:0009725: response to hormone9.11E-03
114GO:0006094: gluconeogenesis9.11E-03
115GO:0009767: photosynthetic electron transport chain9.11E-03
116GO:0005986: sucrose biosynthetic process9.11E-03
117GO:0030048: actin filament-based movement9.11E-03
118GO:0000165: MAPK cascade9.31E-03
119GO:0007049: cell cycle9.73E-03
120GO:0009934: regulation of meristem structural organization9.92E-03
121GO:0010143: cutin biosynthetic process9.92E-03
122GO:0048440: carpel development9.92E-03
123GO:0019253: reductive pentose-phosphate cycle9.92E-03
124GO:0010223: secondary shoot formation9.92E-03
125GO:0009887: animal organ morphogenesis9.92E-03
126GO:0009809: lignin biosynthetic process1.04E-02
127GO:0030154: cell differentiation1.05E-02
128GO:0009611: response to wounding1.06E-02
129GO:0009225: nucleotide-sugar metabolic process1.07E-02
130GO:0007031: peroxisome organization1.07E-02
131GO:0010167: response to nitrate1.07E-02
132GO:0005985: sucrose metabolic process1.07E-02
133GO:0010224: response to UV-B1.07E-02
134GO:0006833: water transport1.16E-02
135GO:0009833: plant-type primary cell wall biogenesis1.16E-02
136GO:0006487: protein N-linked glycosylation1.25E-02
137GO:0019953: sexual reproduction1.34E-02
138GO:0009695: jasmonic acid biosynthetic process1.34E-02
139GO:0031408: oxylipin biosynthetic process1.43E-02
140GO:0006366: transcription from RNA polymerase II promoter1.43E-02
141GO:0051260: protein homooligomerization1.43E-02
142GO:0042545: cell wall modification1.44E-02
143GO:0051726: regulation of cell cycle1.57E-02
144GO:0009742: brassinosteroid mediated signaling pathway1.57E-02
145GO:0010584: pollen exine formation1.72E-02
146GO:0048443: stamen development1.72E-02
147GO:0042127: regulation of cell proliferation1.72E-02
148GO:0016042: lipid catabolic process1.76E-02
149GO:0015991: ATP hydrolysis coupled proton transport1.93E-02
150GO:0000271: polysaccharide biosynthetic process1.93E-02
151GO:0042335: cuticle development1.93E-02
152GO:0034220: ion transmembrane transport1.93E-02
153GO:0046686: response to cadmium ion1.95E-02
154GO:0009741: response to brassinosteroid2.03E-02
155GO:0006520: cellular amino acid metabolic process2.03E-02
156GO:0007059: chromosome segregation2.14E-02
157GO:0015986: ATP synthesis coupled proton transport2.14E-02
158GO:0009791: post-embryonic development2.25E-02
159GO:0019252: starch biosynthetic process2.25E-02
160GO:0008654: phospholipid biosynthetic process2.25E-02
161GO:0071554: cell wall organization or biogenesis2.36E-02
162GO:0007264: small GTPase mediated signal transduction2.47E-02
163GO:0010583: response to cyclopentenone2.47E-02
164GO:0016032: viral process2.47E-02
165GO:0019761: glucosinolate biosynthetic process2.47E-02
166GO:0045490: pectin catabolic process2.56E-02
167GO:1901657: glycosyl compound metabolic process2.59E-02
168GO:0016125: sterol metabolic process2.71E-02
169GO:0009828: plant-type cell wall loosening2.71E-02
170GO:0009414: response to water deprivation2.83E-02
171GO:0051607: defense response to virus2.95E-02
172GO:0009911: positive regulation of flower development3.07E-02
173GO:0009788: negative regulation of abscisic acid-activated signaling pathway3.19E-02
174GO:0010029: regulation of seed germination3.19E-02
175GO:0016311: dephosphorylation3.58E-02
176GO:0045944: positive regulation of transcription from RNA polymerase II promoter3.67E-02
177GO:0009817: defense response to fungus, incompatible interaction3.71E-02
178GO:0030244: cellulose biosynthetic process3.71E-02
179GO:0009416: response to light stimulus3.73E-02
180GO:0009832: plant-type cell wall biogenesis3.84E-02
181GO:0009407: toxin catabolic process3.97E-02
182GO:0010218: response to far red light3.97E-02
183GO:0007568: aging4.11E-02
184GO:0051301: cell division4.15E-02
185GO:0009867: jasmonic acid mediated signaling pathway4.39E-02
186GO:0009637: response to blue light4.39E-02
187GO:0006839: mitochondrial transport4.81E-02
188GO:0006631: fatty acid metabolic process4.95E-02
RankGO TermAdjusted P value
1GO:0050281: serine-glyoxylate transaminase activity0.00E+00
2GO:0016719: carotene 7,8-desaturase activity0.00E+00
3GO:0016210: naringenin-chalcone synthase activity0.00E+00
4GO:0047213: anthocyanidin 3-O-glucosyltransferase activity0.00E+00
5GO:0050278: sedoheptulose-bisphosphatase activity0.00E+00
6GO:0052887: 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity0.00E+00
7GO:0047974: guanosine deaminase activity0.00E+00
8GO:0004760: serine-pyruvate transaminase activity0.00E+00
9GO:0030795: jasmonate O-methyltransferase activity0.00E+00
10GO:0047230: flavonol-3-O-glucoside L-rhamnosyltransferase activity0.00E+00
11GO:0033961: cis-stilbene-oxide hydrolase activity0.00E+00
12GO:0050505: hydroquinone glucosyltransferase activity0.00E+00
13GO:0102078: methyl jasmonate methylesterase activity0.00E+00
14GO:0052886: 9,9'-dicis-carotene:quinone oxidoreductase activity0.00E+00
15GO:1990055: phenylacetaldehyde synthase activity0.00E+00
16GO:0016757: transferase activity, transferring glycosyl groups2.12E-07
17GO:0045430: chalcone isomerase activity3.99E-05
18GO:0008429: phosphatidylethanolamine binding9.33E-05
19GO:0003987: acetate-CoA ligase activity2.39E-04
20GO:0004013: adenosylhomocysteinase activity2.39E-04
21GO:0047760: butyrate-CoA ligase activity2.39E-04
22GO:0010313: phytochrome binding2.39E-04
23GO:0090448: glucosinolate:proton symporter activity2.39E-04
24GO:0004001: adenosine kinase activity2.39E-04
25GO:0004837: tyrosine decarboxylase activity2.39E-04
26GO:0004860: protein kinase inhibitor activity5.19E-04
27GO:0004047: aminomethyltransferase activity5.29E-04
28GO:0010280: UDP-L-rhamnose synthase activity5.29E-04
29GO:0080102: 3-methylthiopropyl glucosinolate S-oxygenase activity5.29E-04
30GO:0042132: fructose 1,6-bisphosphate 1-phosphatase activity5.29E-04
31GO:0080104: 5-methylthiopropyl glucosinolate S-oxygenase activity5.29E-04
32GO:0000064: L-ornithine transmembrane transporter activity5.29E-04
33GO:0050377: UDP-glucose 4,6-dehydratase activity5.29E-04
34GO:0004512: inositol-3-phosphate synthase activity5.29E-04
35GO:0080106: 7-methylthiopropyl glucosinolate S-oxygenase activity5.29E-04
36GO:0048531: beta-1,3-galactosyltransferase activity5.29E-04
37GO:0008460: dTDP-glucose 4,6-dehydratase activity5.29E-04
38GO:0004148: dihydrolipoyl dehydrogenase activity8.60E-04
39GO:0080103: 4-methylthiopropyl glucosinolate S-oxygenase activity8.60E-04
40GO:0003983: UTP:glucose-1-phosphate uridylyltransferase activity8.60E-04
41GO:0071917: triose-phosphate transmembrane transporter activity8.60E-04
42GO:0008194: UDP-glycosyltransferase activity1.04E-03
43GO:0001872: (1->3)-beta-D-glucan binding1.23E-03
44GO:0004375: glycine dehydrogenase (decarboxylating) activity1.23E-03
45GO:0048027: mRNA 5'-UTR binding1.23E-03
46GO:0080107: 8-methylthiopropyl glucosinolate S-oxygenase activity1.23E-03
47GO:0003830: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity1.23E-03
48GO:0035251: UDP-glucosyltransferase activity1.25E-03
49GO:0016655: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor1.64E-03
50GO:0008453: alanine-glyoxylate transaminase activity1.64E-03
51GO:0080032: methyl jasmonate esterase activity1.64E-03
52GO:0098599: palmitoyl hydrolase activity1.64E-03
53GO:0046527: glucosyltransferase activity1.64E-03
54GO:0004301: epoxide hydrolase activity1.64E-03
55GO:0015120: phosphoglycerate transmembrane transporter activity1.64E-03
56GO:0016788: hydrolase activity, acting on ester bonds1.75E-03
57GO:0045547: dehydrodolichyl diphosphate synthase activity2.09E-03
58GO:0002094: polyprenyltransferase activity2.09E-03
59GO:0031386: protein tag2.09E-03
60GO:0004356: glutamate-ammonia ligase activity2.09E-03
61GO:0080044: quercetin 7-O-glucosyltransferase activity2.16E-03
62GO:0080043: quercetin 3-O-glucosyltransferase activity2.16E-03
63GO:0019901: protein kinase binding2.34E-03
64GO:0080030: methyl indole-3-acetate esterase activity2.57E-03
65GO:0008474: palmitoyl-(protein) hydrolase activity2.57E-03
66GO:0000210: NAD+ diphosphatase activity2.57E-03
67GO:0016208: AMP binding2.57E-03
68GO:0004366: glycerol-3-phosphate O-acyltransferase activity2.57E-03
69GO:0102229: amylopectin maltohydrolase activity2.57E-03
70GO:0042578: phosphoric ester hydrolase activity2.57E-03
71GO:0090447: glycerol-3-phosphate 2-O-acyltransferase activity2.57E-03
72GO:0008519: ammonium transmembrane transporter activity2.57E-03
73GO:0052689: carboxylic ester hydrolase activity2.76E-03
74GO:0016759: cellulose synthase activity3.03E-03
75GO:0008195: phosphatidate phosphatase activity3.09E-03
76GO:0045156: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity3.09E-03
77GO:0016161: beta-amylase activity3.09E-03
78GO:0016758: transferase activity, transferring hexosyl groups3.11E-03
79GO:0005215: transporter activity3.27E-03
80GO:0102425: myricetin 3-O-glucosyltransferase activity3.64E-03
81GO:0102360: daphnetin 3-O-glucosyltransferase activity3.64E-03
82GO:0016621: cinnamoyl-CoA reductase activity3.64E-03
83GO:0043295: glutathione binding3.64E-03
84GO:0047893: flavonol 3-O-glucosyltransferase activity4.23E-03
85GO:0004714: transmembrane receptor protein tyrosine kinase activity4.23E-03
86GO:0030247: polysaccharide binding4.25E-03
87GO:0046910: pectinesterase inhibitor activity4.44E-03
88GO:0004693: cyclin-dependent protein serine/threonine kinase activity5.18E-03
89GO:0016207: 4-coumarate-CoA ligase activity5.48E-03
90GO:0004575: sucrose alpha-glucosidase activity6.15E-03
91GO:0015112: nitrate transmembrane transporter activity6.15E-03
92GO:0047372: acylglycerol lipase activity7.58E-03
93GO:0046961: proton-transporting ATPase activity, rotational mechanism7.58E-03
94GO:0046982: protein heterodimerization activity8.26E-03
95GO:0004089: carbonate dehydratase activity9.11E-03
96GO:0008083: growth factor activity9.92E-03
97GO:0042973: glucan endo-1,3-beta-D-glucosidase activity9.92E-03
98GO:0051119: sugar transmembrane transporter activity1.07E-02
99GO:0003824: catalytic activity1.07E-02
100GO:0045330: aspartyl esterase activity1.15E-02
101GO:0102336: 3-oxo-arachidoyl-CoA synthase activity1.16E-02
102GO:0102337: 3-oxo-cerotoyl-CoA synthase activity1.16E-02
103GO:0102338: 3-oxo-lignoceronyl-CoA synthase activity1.16E-02
104GO:0016787: hydrolase activity1.19E-02
105GO:0001046: core promoter sequence-specific DNA binding1.25E-02
106GO:0051087: chaperone binding1.34E-02
107GO:0004650: polygalacturonase activity1.35E-02
108GO:0030599: pectinesterase activity1.39E-02
109GO:0004176: ATP-dependent peptidase activity1.43E-02
110GO:0016746: transferase activity, transferring acyl groups1.52E-02
111GO:0047262: polygalacturonate 4-alpha-galacturonosyltransferase activity1.53E-02
112GO:0004553: hydrolase activity, hydrolyzing O-glycosyl compounds1.56E-02
113GO:0016760: cellulose synthase (UDP-forming) activity1.62E-02
114GO:0004499: N,N-dimethylaniline monooxygenase activity1.72E-02
115GO:0005507: copper ion binding1.74E-02
116GO:0016829: lyase activity2.01E-02
117GO:0000977: RNA polymerase II regulatory region sequence-specific DNA binding2.11E-02
118GO:0016853: isomerase activity2.14E-02
119GO:0005355: glucose transmembrane transporter activity2.14E-02
120GO:0004872: receptor activity2.25E-02
121GO:0048038: quinone binding2.36E-02
122GO:0015297: antiporter activity2.45E-02
123GO:0004518: nuclease activity2.47E-02
124GO:0016791: phosphatase activity2.71E-02
125GO:0008483: transaminase activity2.83E-02
126GO:0016722: oxidoreductase activity, oxidizing metal ions2.83E-02
127GO:0008237: metallopeptidase activity2.83E-02
128GO:0016413: O-acetyltransferase activity2.95E-02
129GO:0015250: water channel activity3.07E-02
130GO:0008375: acetylglucosaminyltransferase activity3.32E-02
131GO:0102483: scopolin beta-glucosidase activity3.45E-02
132GO:0004222: metalloendopeptidase activity3.97E-02
133GO:0001228: transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding4.11E-02
134GO:0050897: cobalt ion binding4.11E-02
135GO:0003993: acid phosphatase activity4.53E-02
136GO:0050660: flavin adenine dinucleotide binding4.57E-02
137GO:0008422: beta-glucosidase activity4.67E-02
138GO:0016740: transferase activity4.76E-02
139GO:0050661: NADP binding4.81E-02
140GO:0004497: monooxygenase activity4.89E-02
RankGO TermAdjusted P value
1GO:0097708: intracellular vesicle0.00E+00
2GO:0031225: anchored component of membrane9.44E-05
3GO:0009344: nitrite reductase complex [NAD(P)H]2.39E-04
4GO:0009505: plant-type cell wall3.62E-04
5GO:0033178: proton-transporting two-sector ATPase complex, catalytic domain5.29E-04
6GO:0009507: chloroplast6.41E-04
7GO:0042406: extrinsic component of endoplasmic reticulum membrane8.60E-04
8GO:0009509: chromoplast8.60E-04
9GO:0005794: Golgi apparatus9.13E-04
10GO:0009941: chloroplast envelope1.21E-03
11GO:0005775: vacuolar lumen1.23E-03
12GO:0005960: glycine cleavage complex1.23E-03
13GO:0046658: anchored component of plasma membrane1.34E-03
14GO:0009506: plasmodesma1.71E-03
15GO:0071944: cell periphery2.85E-03
16GO:0005783: endoplasmic reticulum3.59E-03
17GO:0005886: plasma membrane4.53E-03
18GO:0048046: apoplast4.69E-03
19GO:0005779: integral component of peroxisomal membrane4.84E-03
20GO:0010598: NAD(P)H dehydrogenase complex (plastoquinone)5.48E-03
21GO:0016021: integral component of membrane6.04E-03
22GO:0005765: lysosomal membrane7.58E-03
23GO:0048471: perinuclear region of cytoplasm7.58E-03
24GO:0031012: extracellular matrix9.11E-03
25GO:0019013: viral nucleocapsid9.11E-03
26GO:0030095: chloroplast photosystem II9.92E-03
27GO:0005753: mitochondrial proton-transporting ATP synthase complex1.07E-02
28GO:0009654: photosystem II oxygen evolving complex1.34E-02
29GO:0000139: Golgi membrane1.53E-02
30GO:0009543: chloroplast thylakoid lumen1.86E-02
31GO:0005576: extracellular region2.04E-02
32GO:0043231: intracellular membrane-bounded organelle2.06E-02
33GO:0016020: membrane2.09E-02
34GO:0019898: extrinsic component of membrane2.25E-02
35GO:0009705: plant-type vacuole membrane2.56E-02
36GO:0005887: integral component of plasma membrane2.68E-02
37GO:0005778: peroxisomal membrane2.83E-02
38GO:0005829: cytosol2.90E-02
39GO:0005618: cell wall3.78E-02
40GO:0000325: plant-type vacuole4.11E-02
41GO:0009570: chloroplast stroma4.21E-02
42GO:0005777: peroxisome4.42E-02
43GO:0009579: thylakoid4.65E-02
44GO:0005819: spindle4.67E-02
45GO:0031902: late endosome membrane4.95E-02
Gene type



Gene DE type